المستودع الأكاديمي جامعة المدينة

Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

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dc.contributor Traber, Maret G.
dc.contributor Ho, Emily
dc.contributor Manore, Melinda
dc.contributor Cherian, Gita
dc.date 2007-06-18T19:48:57Z
dc.date 2007-06-18T19:48:57Z
dc.date 2007-05-23
dc.date 2007-06-18T19:48:57Z
dc.date.accessioned 2013-10-16T07:52:24Z
dc.date.available 2013-10-16T07:52:24Z
dc.date.issued 2013-10-16
dc.identifier http://hdl.handle.net/1957/5495
dc.identifier.uri http://koha.mediu.edu.my:8181/xmlui/handle/1957/5495
dc.description Graduation date: 2008
dc.description In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl acetates were administered to male (n=5) and female (n=5) volunteers. Tocopherol and CEHC concentrations were followed for 72 h. Sesame lignan consumption significantly increased plasma d2-γ-TOH concentrations (p<0.05). In men, sesame lignans increased plasma d2-γ-tocopherol areas under the curve (AUC; sesame oil: 34.3 ± 4.6; corn oil: 28.9 ± 3.3 μmol/L·h, p<0.01) and reduced d2-γ-CEHC AUCs (p<0.05). In men, differences in urinary d2-γ-CEHC AUCs did not reach statistical significance (AUCs for 24 h, corn oil: 11.2 ± 3.0 μmol/g creatinine·h; vs sesame oil: 5.0 ± 1.5). In women, sesame lignan consumption did not alter plasma tocopherol CEHC concentrations but reduced urinary d2-γ-CEHC excretion (AUCs for 24 h, corn oil: 19.3 ± 4.9 μmol/g creatinine·h; and sesame oil: 7.7 ± 2.0, p < 0.05). These data suggest that sesame lignans alter γ-tocopherol metabolism differently in men and women. Further research is needed to assess the mechanism involved in these differences.
dc.language en_US
dc.subject vitamin E
dc.subject gamma-tocopherol
dc.subject sesame lignan
dc.subject omega-hydroxylase
dc.subject Carboxyethyl hydroxychromanols
dc.subject CEHC
dc.subject sesamin
dc.subject sesamolin
dc.subject gender differences
dc.subject kinetics
dc.title Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans
dc.type Thesis


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