Symmetry energy coefficients of asymmetric nuclear matter generalized are investigated as the inverse of nuclear matter polarizabilities with two different approaches. Firstly a general calculation shows they may depend on the neutron-proton asymmetry itself. The choice of particular prescriptions for the density fluctuations lead to certain isospin (n-p asymmetry) dependences of the polarizabilities. Secondly, with Skyrme type interactions, the static limit of the dynamical polarizability is investigated corresponding to the inverse symmetry energy coefficient which assumes different values at different asymmetries (and densities and temperatures). The symmetry energy coefficient (in the isovector channel) is found to increase as n-p asymmetries increase. The spin symmetry energy coefficient is also briefly investigated.