The aim of this study was investigation of the effect of glucose on plasma ghrelin; GH; andglucose after a single session of aerobic exercise in young man.Material and Method: Twelve Unathletic student men separated randomly in two groups (glucoseand water). Consecutive-one mail running was performed; with 3 min resting in the end of eachmail. Blood samples were taken at before; immediately and 90min after exercise. Plasma ghrelin;GH and glucose were measured. Possible statistically significant differences were determined bytwo-factor ANOVA for repeated were employed. The difference detected by ANOVA werelocated with a LSD (with Benferoni correction) post hoc test.Results: showed that ghrelin and GH significantly increased immediately after exercise.Discussion: Data indicate that a higher ghrelin in the present study might be attributed a liverglycogen and ATP deficiency and an incomplete energy source recovery after exercise.