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Neurological Soft Signs in Bipolar Disorder: The Impact of Comorbid Attention Deficit Hyperactivity Disorder Research Article

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dc.creator Halide Tüysüzoğlu
dc.creator Figen Ç. Ateşci
dc.creator Osman Özdel
dc.creator Nalan Kalkan Oğuzhanoğlu
dc.date 2011
dc.date.accessioned 2013-05-30T14:05:28Z
dc.date.available 2013-05-30T14:05:28Z
dc.date.issued 2013-05-30
dc.identifier http://www.turknoropsikiyatri.org/default.aspx?pfn=dergiOkur&iid=51&modulePage=article&dt=tft&aid=315
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=13000667&date=2011&volume=48&issue=2&spage=107
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/6028
dc.description Objective: Attention deficit hyperactivity disorder (ADHD) and bipolar disorder are frequently comorbid diagnoses. Aim of this study was to compare the neurological soft signs in patients with bipolar disorder and in patients with comorbid ADHD to those in control subjects. This study helps us to understand the impact of ADHD on the soft neurological signs in bipolar disorder in adults.Methods: Sixty euthymic patients diagnosed with bipolar I disorder and 33 healthy control subjects were enrolled in the study. The Wender Utah Rating Scale, Adult ADHD Rating Scale and The Structured Clinical Interview for DSM-IV Disorders were administered to the participants. The subjects were classified into three study groups, namely, bipolar patients with comorbid ADHD (n=13), bipolar patients without comorbid ADHD (n=47) and controls. We performed the Neurological Evaluation Scale in the three groups. Results: Comorbid ADHD group showed poor performance on complex motor tasks such as fist-ring test and fist-edge–palm test, while bipolar group showed poor performance on Ozeretski test. Comorbid ADHD patients performed poorly on graphestesia, stereognosis and primitive reflexes. Conclusion: Abnormalities of repetitive motor performance and primitive reflexes observed in comorbid ADHD patients support the hypothesis that ADHD involves a deficit in fronto–striatal-thalamic neurocircuits. In contrast, impaired sequential motor performance in BP subjects shows deficits in dorsolateral prefrontal cortex. These results show that the pathophysiology of bipolar disorder and ADHD may be related to different areas, and comorbid ADHD may increase the severity of the soft neurological signs. (Archives of Neuropsychiatry 2011; 48: 107-13)
dc.publisher Galenos Yayicilik
dc.source Nöropsikiyatri Arşivi
dc.subject Bipolar disorder
dc.subject attention deficit disorder with hyperactivity
dc.subject adults
dc.subject neurological soft signs
dc.title Neurological Soft Signs in Bipolar Disorder: The Impact of Comorbid Attention Deficit Hyperactivity Disorder Research Article


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