Introduction: Colloid cysts represent 0.5-1% of all intracranial neoplasms and 55% of the third ventricular lesions. In this study, we emphasized the principles of treatment in pediatric cases with third venricular colloid cysts treated by using anterior interhemispheric transcallosal approach. Materials and Method: The patients aged 16 years and below with colloid cysts, operated between 2001-2009, were evaluated retrospectively.Results: There were 3 males and 1 female patients aged between 12-16 (mean age 13.75) years. The mean duration of symptoms were 2.5 months and mean duration of follow-up 46.75 (15-102) months. All the patients had frontal headache as a main complaint; 2 patients also had nausea and vomiting; and 1 patient also had numbness on the left side of his body. Three patients had bilateral marked papil edema while 1 patient had no neurological deficit. Cyst was hyperintense and hypointense in cranial computed tomography of 2 and 1 patients, respectively. T1-, and T2-weighted cranial magnetic resonance images were iso-, and hyperintense in 2 patients while hypo-, and hyperintense in 1 patient, while hyper-, and isointense in 1 patient respectively. Interhemispheric-transcallosal-transforaminal approach was used in all patients. In 3 patients, total excision was performed while in 1 patient, a small part of capsule attached to thalamostriate vein was left. There were no cyst recurrences at follow-up.Conclusions: Although various approaches had been described to reach the third ventricular colloid cyst; we preferred the transcallosal approach in all of our pediatric patients since the approach does not cause any cortical breach and provides secure tumour resection. (Journal of Current Pediatrics 2011; 9: 23-7)