Resistance exercise ameliorates metabolic and endocrine profile; reduces muscle deteriorationduring aging and develops performance in older adults. This study examined the effects ofresistance training on serum visfatin levels and HOMA-IR in sedentary menopausal women.Participants included 16 obese women mean age 54 years studied in two control and exercisegroups before and after 10 weeks of resistance training (3 days/week at 40-60% of 1RM).Serum level of visfatin; HOMA-IR and anthropometric indices were measured before and 48hours after last training session. Resistance training significantly modulated neither visfatinlevel nor HOMA-IR and any significant changes did not exist for anthropometric factors(P>0.05). pearson correlation did not show significant correlation between the primary level andalterations of visfatin and primary and changed values of HOMA-IR and anthropometric factorsin resistance groups (P>0.05). Therefore resistance training doesn’t change visfatinconcentrations without influence on HOMA-IR and anthropometric indices in sedentarymenopausal obese women aged 45-60 years old.