The three hormones adiponectin; leptin and resistin due to their association with inflammatoryand metabolic; play a vital role in diseases caused by obesity. Researchers want to know ifaerobic exercises can bring to desirable plasma levels of these hormones. For this purpose 30healthy middle-aged men were divided into two groups and 15 of them participate in an eightweeks aerobics training program. Blood samples were collected before and after trainingprogram. Results indicate that the experimental group in addition to reducing fat; increasing theamount of plasma adiponectin and Resistin. Plasma leptin levels also decreased. According toprevious studies the researchers concluded that aerobic exercise regulates the hormone toideally amount that help preventing disease.