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Simultaneous Determination and validation of Ziprasidone Hydrochloride in Dosage form by Densitometric

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dc.creator M.C. Sharma, S. Sharma , A.D. Sharma
dc.date 2011
dc.date.accessioned 2013-05-30T13:18:45Z
dc.date.available 2013-05-30T13:18:45Z
dc.date.issued 2013-05-30
dc.identifier http://ditonline.info/article/view/8120/4146
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=09757619&date=2011&volume=3&issue=6&spage=102
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/5705
dc.description A simple, rapid and accurate High-performance thin-layer chromatography method has been established and validated for the simultaneous determination of Ziprasidone Hydrochloride in tablets. The method is based on HPTLC separation of the drugs followed by densitometric measurements of their spots at 277 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60F-254 using mobile phase consisting of benzene: ethyl acetate: methanol: glacial acetic acid (4.0: 1.0:0.5:0.1 v/v/v/v). Calibration curves were linear in range of 1.625- 14.625 μg/spot and 0.1 - 0.9 μg/spot for Ziprasidone Hydrochloride.
dc.publisher Association of Pharmaceutical Innovators
dc.source Drug Invention Today
dc.subject Ziprasidone hydrochloride
dc.subject HPTLC
dc.subject Validation
dc.title Simultaneous Determination and validation of Ziprasidone Hydrochloride in Dosage form by Densitometric


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