A simple, rapid and accurate High-performance thin-layer chromatography method has been established and validated for the simultaneous determination of Ziprasidone Hydrochloride in tablets. The method is based on HPTLC separation of the drugs followed by densitometric measurements of their spots at 277 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60F-254 using mobile phase consisting of benzene: ethyl acetate: methanol: glacial acetic acid (4.0: 1.0:0.5:0.1 v/v/v/v). Calibration curves were linear in range of 1.625- 14.625 μg/spot and 0.1 - 0.9 μg/spot for Ziprasidone Hydrochloride.