| dc.creator |
M.C. Sharma, S. Sharma*, A.D. Sharma |
|
| dc.date |
2011 |
|
| dc.date.accessioned |
2013-05-30T13:18:14Z |
|
| dc.date.available |
2013-05-30T13:18:14Z |
|
| dc.date.issued |
2013-05-30 |
|
| dc.identifier |
http://ditonline.info/article/view/8119/4145 |
|
| dc.identifier |
http://www.doaj.org/doaj?func=openurl&genre=article&issn=09757619&date=2011&volume=3&issue=6&spage=100 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/jspui/handle/123456789/5701 |
|
| dc.description |
A RP-HPLC method was developed and validated for quantitative determination of Atenolol and Hydrochlorothiazide in pharmaceutical dosage forms. The chromatography was carried out on a 25 cm × 4.6 mm i.d, 5-μm particle, Phenomenex Luna C18 column under reversed-phase partition chromatographic conditions. The mobile phase was a mixture of ammonium acetate (0.02M, pH 4.0 adjusted with glacial acetic acid) and acetonitrile in ratio of 40:60 (v/v) at a flow rate of 1.0ml/min. Clarithromycin was used as an internal standard. The linearity was established in the range of 20 - 400 ng/ml Atenolol and 5-150 ng/ml Hydrochlorothiazide for HPLC. This validated method can be used for estimation of Atenolol and Hydrochlorothiazide in pharmaceutical suspension. |
|
| dc.publisher |
Association of Pharmaceutical Innovators |
|
| dc.source |
Drug Invention Today |
|
| dc.subject |
Atenolol |
|
| dc.subject |
Hydrochlorothiazide |
|
| dc.subject |
RP-HPLC |
|
| dc.subject |
Analytical method validation |
|
| dc.title |
Application to Dissolution Assessments; A Facile and Rapid procedure of Atenolol and Hydrochlorothiazide in Pharmaceutical Formulation by RP-HPLC assay Method |
|