المستودع الأكاديمي جامعة المدينة

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

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dc.creator Khalid O. Alfarouk
dc.creator Mohammed E.A. Shayoub
dc.creator Abdel Khalig Muddathir
dc.creator Gamal O. Elhassan
dc.creator Adil H.H. Bashir
dc.date 2011
dc.date.accessioned 2013-05-30T13:10:12Z
dc.date.available 2013-05-30T13:10:12Z
dc.date.issued 2013-05-30
dc.identifier http://www.mdpi.com/2072-6694/3/3/3002/
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=20726694&date=2011&volume=3&issue=3&spage=3002
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/5637
dc.description Carcinogenesis occurs through a series of steps from normal into benign and finally malignant phenotype. This cancer evolutionary trajectory has been accompanied by similar metabolic transformation from normal metabolism into Pasteur and/or Crabtree-Effects into Warburg-Effect and finally Cannibalism and/or Lactate-Symbiosis. Due to lactate production as an end-product of glycolysis, tumor colonies acquire new phenotypes that rely on lactate as energetic fuel. Presence of Warburg-Effect indicates that some tumor cells undergo partial (if not complete) de-endosymbiosis and so cancer cells have been become unicellular microorganism (anti-Dollo’s Law) specially when they evolve to develop cannibalism as way of metabolism while oxidative types of cells that rely on lactate, as their energetic fuel, might represent extra-endosymbiosis. Thus, at the end, the cancer colony could be considered as integrated metabolic ecosystem. Proper understanding of tumor metabolism will contribute to discover potential anticancer agents besides conventional chemotherapy.
dc.language eng
dc.publisher Molecular Diversity Preservation International
dc.source Cancers
dc.subject Warburg-effect
dc.subject Crabtree-effect
dc.subject Pasteur-effect
dc.subject lactate symbiosis
dc.subject cannibalism
dc.subject reverse evolution
dc.subject convergent evolution
dc.title Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)


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