Enzo Maria Vingolo1,2, Mariacristina Esposito3, Aloisa Librando3, Yu-Hui Huang4, Serena Salvatore1,21Department of Ophthalmology, University La Sapienza of Rome, Terracina, Italy; 2UOC Santa Maria Goretti Hospital, Latina, Italy; 3Department of Ophthalmology, University La Sapienza of Rome, Rome, Italy; 4University of Illinois at Chicago, Chicago, IL, USABackground: The purpose of the study was to evaluate vitreoretinal interface (VRI) alteration with a short-wavelength scanning laser ophthalmoscope (swSLO), the Nidek F-10, and compare the results with those obtained by means of spectral-domain optical coherence tomography (SD-OCT).Methods: Thirty-six eyes were studied (20 patients, mean age 68 ± 12.3 years). All patients underwent a complete ophthalmologic examination, which comprised SD-OCT and Nidek F-10 analysis with short-wavelength blue laser. Eyes were divided into four groups depending on the degree of VRI alteration observed with the swSLO and SD-OCT. Statistical analysis was performed using the Chi-square test. P values less than 0.05 were considered statistically significant.Results: OCT analysis: eight eyes (22%) grade 0 (no abnormalities), 15 eyes (42%) grade 1 (preretinal cellophane); seven (19%) grade 2 (preretinal wrinkling); six (17%) grade 3 (macular pucker or hole). Nidek F-10 analysis: seven (19%) grade 0, 16 (45%) grade 1; seven (19%) grade 2; six (17%) grade 3. Chi-square = 0.099, P = 0.992. There was no statistically significant difference between the two instruments.Conclusion: Nidek F-10 allows both a quantitative and a qualitative evaluation of VRI and is equal to SD-OCT in detecting alteration of the inner portion of the retina, providing an easy way to evaluate and map differences in the inner vitreoretinal surface.Keywords: vitreoretinal interface, macular pucker, macular cellophane, optical coherence tomography (OCT), short wavelength scanning laser ophthalmoscope (swSLO), Nidek F-10