المستودع الأكاديمي جامعة المدينة

Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009

أعرض تسجيلة المادة بشكل مبسط

dc.creator Høyer M
dc.creator Erichsen R
dc.creator Gandrup P
dc.creator Nørgaard M
dc.creator Jacobsen JB
dc.date 2011
dc.date.accessioned 2013-05-30T12:51:19Z
dc.date.available 2013-05-30T12:51:19Z
dc.date.issued 2013-05-30
dc.identifier http://www.dovepress.com/survival-in-patients-with-synchronous-liver-metastases-in-central-and--a7905
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=11791349&date=2011&volume=2011&issue=Supplement+1&spage=11
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/5452
dc.description Morten Høyer1,2, Rune Erichsen1, Per Gandrup3, Mette Nørgaard1, Jacob Bonde Jacobsen11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Oncology, Aarhus University Hospital, Aarhus, Denmark; 3Department of Gastrointestinal Surgery, Aarhus University Hospital, Aalborg, DenmarkObjective: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorectal carcinoma (CRC) or other solid tumors (non-CRC) who had liver metastases at time of diagnosis.Study design and methods: We included patients diagnosed with liver metastases synchronous with a primary cancer (ie, a solid cancer diagnosed at the same date or within 60 days after liver metastasis diagnosis) during the period 1998 to 2009 identified through the Danish National Registry of Patients. We followed those who survived for more than 60 days in a survival analysis (n = 1021). Survival and mortality rate ratio (MRR) at 1, 3, and 5 years stratified by year of diagnosis were estimated using Cox proportional hazards regression analysis.Results: In the total study population of 1021 patients, 541 patients had a primary CRC and 480 patients non-CRC. Overall, the 5-year survival improved from 3% (95% confidence interval [CI]: 1%–6%) in 1998–2000 to 10% (95% CI: 6%–14%) in 2007 to 2009 (predicted value). The 5-year survival for CRC-patients improved from 1% (95% CI: 0%–5%) to 11% (95% CI: 6%–18%) whereas survival for non-CRC patients only increased from 5% (95% CI: 1%–10%) to 8% (95% CI: 4%–14%).Conclusion: We observed improved survival in patients with liver metastases in a time period characterized by introduction of a structured multidisciplinary care and improved treatment options. The survival gain was most prominent for CRC-patients.Keywords: liver metastases, colorectal cancer, noncolorectal cancer, survival improvement
dc.language eng
dc.publisher Dove Press
dc.source Clinical Epidemiology
dc.title Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009


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