The purpose of this study is to determine the effect of moderate and intensity aerobic exerciseon serum leptin levels in obese/overweight women.Methods: The study group which include forty five obese/overweight women were selectedfrom patients of Iranian Health Clinic in Isfahan city that were qualified (BMI≥25-30kg/m2) toparticipate at this design. Serum leptin levels of patients were evaluated before eating thebreakfast and fat percent were measured by lunch caliper. Participants were randomizedcategorized in three group: 1) Moderate aerobic exercise (45-50% HRRMAX); 2) Intensityaerobic exercise (70-75% HRRMAX); 3) Control group (without training). Training is 10weeks; (with three sessions in every week); the time devoted for every session was 60 minutes.The training protocol is aerobic exercise which is made by the researcher. After 10 weeksassessment was down for second time. Pre and post test data was analyzed by ANOVA andshefe.Results show that moderate and intensity aerobic exercise has a significant effect on bodyweight (p<0/000); fat percent (p<0/03); BMI (P<0/001) and Serum leptin levels(p<0/000).This research suggests that intensity aerobic exercise has a comparatively more effective effectthan moderate aerobic exercise on serum leptin levels. We can arrived to this fact by comparingthe obtained data of two mentioned groups with control group. In finally we can result thatmaybe intensity aerobic exercise training is effective than moderate aerobic exercise training inbody weight regulation and serum leptin levels.