The purpose of the present study was to examine the effect of an acute bout of postprandialprior exercise with 70 percent VO2max on markers of inflammation (sVCAM-1) following ahigh fat meal in non-athlete men.Methods: we assigned 20 non-athlete students in a random fashion and based on their body fatto 2 groups of 10 people; one experimental (averaging 21.98±1.30 years; 18.04±2.48 bodyweight percent) and control (averaging 22.06 ±1.22 years; 18.15±3.54 body weight percentage)groups. The experimental group completed a 90-minute treadmill exercise. A day later bothgroups received high fat meal. Blood samples in 30 min before and 30 min; 1; 3 and 24 hoursfollowing meal were collected. To determine normality of groups; we carried out one sampleKolmogrov smirnov ( PCON= 0.996) ( PEX=0.999) and to determine the homogeneity ofvariances we used Leven test and to examine results among and inter- groups independent t-testand statistical test for variance analysis with repeated measures and post-hoc LSD test.Results: our results indicated that one bout of acute prior aerobic exercise reduces sVCAM-1(P=0.029). Also in 30min and 24 hours following high fat meal there is a reduction of sVCAM-1.Conclusion: high fat meal increases sVCAM-1; thus leading to inflammation and diseases.Exercise may be able to reduce sVCAM-1 and hence reducing the risk of cardiovasculardiseases.