The purpose of this study was to investigate the role of fatigue on strength gain in resistancetraining by comparing high fatiguing and low fatiguing training protocols. Thirty health adults(age 21.26 ±2.14 yr; height 174 ± 4 cm; weight 71.80 ± 5.83kg) assigned to either a highfatigue (HF: four sets of 10 repetitions with 30 seconds rest between sets); low fatigue (LF: 40repetitions with 30 seconds between each repetition) or control (C: without training) groupsrandomly. Subjects in the two training groups undertook bench press training with three times aweek on average 75% of their 1 repetition maximum (1RM); for 10 week. Results indicated thatbench press training causes a significant increase in pectoral muscle strength in Both HF and LFgroups comparing with C group (p≤0.01). But; Both HF and LF resulted in similar strengthgains in 1-repetition maximum bench press. It seems that fatigue in each set does not appear tobe critical stimuli for strength gain in weight training and we can reach to same results withoutsevere discomfort and acute physical effort.