Garcinia indica Linn (Clusiaceae), a medicinal plant mentioned in Ayurveda has been used for treatment of liver disorders, dysentery, sunstroke, cancer and heart diseases. The present study was undertaken to investigate antioxidant and hepatoprotective effect of aqueous and ethanolic extract of Garcinia indica Linn fruit rind. The aqueous and ethanolic extract of Garcinia indica Linn were studied for their antioxidant and hepatoprotective effects on carbon tetrachloride (1.5 ml/kg) induced liver toxicity on Wistar albino rats. The degree of liver protection was measured by using biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALKP) and serum bilirubin (SBRN). Whereas antioxidant effect was determine by using biochemical parameters like sulphoxide dismutase (SOD), glutathione (GSH), lipid peroxidation (LPO) and catalase (CAT). Aqueous and ethanolic extract at a dose level of 500mg/kg produce significant (P<0.01) antioxidant as well as hepatoprotective activity. The effect of aqueous extract was comparable to that of standard drug, silymarin (70 mg/Kg).