Three simple, precise and accurate spectrophotometric methods have been developed for the estimation of Prasugrel in pharmaceutical formulations. Prasugrel exhibits maximum absorbance (λ max) at254.0 nm (Method A). In Method B (D1) is a first derivative method showing minima at 272 nm and Method C is an Area under Curve (AUC) method (244.0-264.0 nm). The drug obeys the Beer-Lambert’s law in the concentration range of 1-50 μg/ml in all the three methods. The methods were validated and can be successfully applied to estimate Prasugrel in pharmaceutical dosage forms.