المستودع الأكاديمي جامعة المدينة

Research:PREPARATION AND CHARACTERIZATION OF LIPOSOMES ENCAPSULATED WITH CLINDAMYCIN AND TRETINOIN

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dc.creator Bizhan Malaekeh-Nikouei
dc.creator Shiva Golmohammadzadeh*
dc.creator Mahshid Hosseini
dc.creator Horiyeh Nassirli
dc.date 2011
dc.date.accessioned 2013-05-30T12:30:01Z
dc.date.available 2013-05-30T12:30:01Z
dc.date.issued 2013-05-30
dc.identifier http://www.pharmacie-globale.info/index.php?option=com_docman&task=doc_view&gid=165&tmpl=component&format=raw&Itemid=41
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=09768157&date=2011&volume=02&issue=06&spage=1
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/5240
dc.description A formulation containing agents affecting the non-inflammatory like tretinoin as well as the inflammatory lesions of acne like clindamycin at the same time is preferable due to their high efficacy and shortening of the duration of treatment. Liposomes can improve the therapeutic effect of drugs and decrease the adverse effects. Therefore, liposomes containing clindamycin (Lip-CL), liposomes containing tretinoin (Lip-TRT) and liposomes loaded with both tretinoin and clindamycin (Lip-CL-TRT) were prepared and characterized. Lip-TRT were prepared by solvent evaporation method whereas Lip-CL and Lip-CL-TRT were prepared by dehydration-rehydration method. The morphologic, mean size and drug encapsulation efficiency were evaluated. Also, the amount of drug which was passed through or retained inside the skin was determined by Franz cell diffusion method and compared with the TRT cream. The particles of the liposomes were obtained in submicron size. The encapsulation efficiency (EE) of TRT and CL were high in the liposomal formulations. The retention of TRT and CL inside the skin from the Lip-CL-TRT were obtained more than 80%. Generally the results of the present study showed that it is possible to select liposomes as drug carrier for both CL and TRT.
dc.publisher Pharmacie Globale
dc.source Pharmacie Globale : International Journal of Comprehensive Pharmacy
dc.subject Acne
dc.subject Liposomes
dc.subject Clindamycin
dc.subject Tretinoin
dc.subject Skin.
dc.title Research:PREPARATION AND CHARACTERIZATION OF LIPOSOMES ENCAPSULATED WITH CLINDAMYCIN AND TRETINOIN


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