المستودع الأكاديمي جامعة المدينة

Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis

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dc.creator Shadi Saghafi
dc.creator Sakineh Amoueian
dc.creator Mehdi Montazer
dc.creator Roshanak Bostan
dc.date 2011
dc.date.accessioned 2013-05-30T12:09:16Z
dc.date.available 2013-05-30T12:09:16Z
dc.date.issued 2013-05-30
dc.identifier http://www.mums.ac.ir/shares/basic_medical/basicmedjou/2011/mar/a12.pdf
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=20083866&date=2011&volume=14&issue=49&spage=
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/5034
dc.description AbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. ResultsThe male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs. 13.6±0.08). There was no statistically significant difference between PG and IG.ConclusionThe current study supports the common nature of pyogenic granulomas and inflammatory gingivitis.
dc.publisher Mashhad University of Medical Sciences
dc.source Iranian Journal of Basic Medical Sciences
dc.subject CD31
dc.subject Gingivitis
dc.subject Hemangioma
dc.subject Ki-67 Antigen
dc.subject Pyogenic Granuloma
dc.subject VEGF
dc.title Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis


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