Ameloblastoma is an epithelial odontogenic tumour of the jaw and exhibits diverse microscopic patterns which occurs either singly or in combination with other patterns. Granular cells can occur in various odontogenic and non-odontogenic tumours. Granular cell ameloblastoma is a rare variant of ameloblastoma as making up 1 to 5% of all ameloblastomas that histopathologically has numerous large granular cells. The “granular change” is thought to be due to a dysfunctional status of neoplastic cells, and the pathogenesis of this tumour seems to be age-related. This article describes a case of granular cell ameloblastoma affecting a 60-year-old woman. The lesion was located in the right side of the mandible. The tumour was excised and no recurrence has been observed after one year of surgery.