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Effects of calcium antagonists on brain ischemia

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dc.creator Naumović Nada
dc.creator Slankamenac Petar
dc.creator Filipović Danka
dc.creator Ivetić Vesna
dc.creator Tomašević-Todorović Snežana
dc.creator Bošković Ksenija
dc.date 2011
dc.date.accessioned 2013-05-30T11:55:31Z
dc.date.available 2013-05-30T11:55:31Z
dc.date.issued 2013-05-30
dc.identifier http://www.doiserbia.nb.rs/img/doi/0025-8105/2011/0025-81051106257N.pdf
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=00258105&date=2011&volume=64&issue=5-6&spage=257
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/4897
dc.description Introduction. Stroke is the second leading cause of death in the world and the leading cause of serious, long term disability in adults; about half of those who survive become dependent on others in performing personal activities of daily living. Ischemia disturbs calcium cellular homeostasis, whereas calcium channel blockers re-establish it. This study was aimed at assessing benefits of calcium channel blockers on the outcome of rehabilitation of the patients afflicted by ischemic stroke. Material and Methods. The functional independence was measured by the Barthel index in 90 patients subjected to rehabilitative therapeutic treatment. The functional recovery of patients treated with calcium channel blockers and with other drugs (control) was compared and tested. Results. The analysis of variance (ANOVA) for the 0.5 confidence interval showed that the increases of the Barthel index values were significantly higher in the patients treated with calcium antagonists (p<0.5). Discussion. According to the literature, such an outcome is the result of improved brain blood f low auto-regulation, increased brain perfusion as well as of neuroprotective, antioxidative, platelet antiaggregatory effects of investigated drugs. Conclusion. The calcium channel blockers improved the outcome of rehabilitative therapeutic treatment significantly in the patients afflicted by ischemic stroke.
dc.publisher Društvo lekara Vojvodine Srpskog lekarskog društva
dc.source Medicinski Pregled
dc.subject Calcium Channel Blockers
dc.subject Brain Ischemia
dc.subject Disability Evaluation
dc.subject Rehabilitation
dc.subject Recovery of Function
dc.subject NON MESH: Barthel index
dc.title Effects of calcium antagonists on brain ischemia


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