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Preoperative assessment and preparation of patients with diseases affecting the central nervous system

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dc.creator Milaković Branko
dc.creator Dimitrijević Ivan
dc.creator Malenković Vesna
dc.creator Marković Dejan
dc.creator Pantić-Palibrk Vesna
dc.creator Gvozdenović Ljiljana
dc.date 2011
dc.date.accessioned 2013-05-30T11:47:00Z
dc.date.available 2013-05-30T11:47:00Z
dc.date.issued 2013-05-30
dc.identifier http://www.doiserbia.nb.rs/img/doi/0354-950X/2011/0354-950X1102083M.pdf
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=0354950X&date=2011&volume=58&issue=2&spage=83
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/4812
dc.description Purpose of review: This review will examine the most important issues of preoperative evaluation and preparation in relation to patients with deseases affecting the central nervous system. Those patients may undergo various forms of surgery unrelated to the central nervous system disease. We discuss the effect of physiologic and pharmacological factors on cerebral autoregulation and control of intracranial pressure alongside its clinical relevance with the help of new evidence. Recent findings: Regardless of the reason for surgery, coexisting diseases of brain often have important implications when selecting anesthetic drugs, procedures and monitoring techniques. Suppression of cerebral metabolic rate is not the sole mechanism for the neuroprotective effect of anaesthetic agents. There are certain general principles, but also some specific circumstances, when we are talking about optimal anesthetic procedure for a patient with coexisting brain disease. Intravenous anesthesia, such as combination of propofol and remifentanil, provides best preservation of autoregulation. Among inhaled agents isoflurane and sevoflurane appear to preserve autoregulation at all doses, whereas with other agents autoregulation is impaired in a dose-related manner. During maintenance of anesthesia the patient is ventilated by intermittent positive pressure ventilation, at intermediate hyperventilation (PaCO2 25 - 30 mmHg). Summary: Intraoperative cerebral autoregulation monitoring is an important consideration for the patients with coexisting neurological disease. Transcranial Doppler based static autoregulation measurements appears to be the most robust bedside method for this purpose.
dc.language eng
dc.publisher Klinički centar Srbije, Institut za bolesti digestivnog sistema
dc.source Acta Chirurgica Iugoslavica
dc.subject central nervous system, disease
dc.subject anesthesia, neurosurgical
dc.subject assessment, preoperative
dc.title Preoperative assessment and preparation of patients with diseases affecting the central nervous system


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