Background: This study analyzes the therapeutic effects of intravenous infusion of iloprost in wound healing,healing of the amputation stump wound, improvement in intermittent claudication and prevention of major amputationin patients with Buerger’s disease.Methods: In a prospective study, 19 patients with known Buerger’s disease, received intravenous iloprost infusion,6 hours per day for 10 days. Iloprost with a dose of 0.5-2 ng/kg/min according to the patients’ tolerance andusing cardiac monitoring during the whole infusion period was administered for 6 hours/day using saline solution.Patients with larger wounds underwent simultaneous transmetatarsal or Ray amputation of the involved toe(s).All patients were discharged after 10 days. Patients were followed to detect their healing changes.Results: Nineteen patients, 19-55 years old received 0.5-2 ng/kg/min iloprost intravenously for 6 hours/day for10 days. During this period, there was relative improvement in resting pain, but no significant amelioration wasnoticed in wound healing. In a 2 years follow-up, 14 patients showed a complete healing of the amputation stumpand increased distance of walking without any pain. Some previous candidates of major amputation did not needamputation anymore. Five patients (26%) did not respond to therapy.Conclusion: Although Buerger’s disease patients who were under iloprost therapy, may not show significantchanges in wound healing during treatment and at discharge, late results have proved that iloprost infusion ispromising in improving wound healing and claudication and preventing major amputations.