Background: Renal transplantation is the best option for treatment of the end-stage renal diseases and hasmore advantages than dialysis. The objective of this study is to determine the ten-year graft survival rate of renaltransplantation and its associated factors in patients who have been transplanted from March 1999 to March2009 in Nemazee Hospital Transplantation Center.Methods: This is a historical cohort study of 1356 renal transplantation carried out during 1999 to 2009. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regressionmodel to determine hazard ratios and for modeling of variables affecting survival.Results: The 1, 3, 5, 7 and 10 years graft survival rates were 96.6, 93.7, 88.9, 87.1 and 85.5 percent, respectively.Cox regression model revealed that the donor source and creatinine level at discharge were effectivefactors in graft survival rate in renal transplantation.Conclusion: Our study showed that 10 year graft survival rate for renal transplantation in Nemazee HospitalTransplantation Center was 85.5% and graft survival rate was significantly related to recipients and donor’s age,donor source and creatinine level at discharge. Our experience in renal transplantation survival rate indicates asuccess rate comparable to those noted in other reports.