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Recent understanding in the treatment of visceral leishmaniasis.

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dc.creator Rosenthal E
dc.creator Marty P
dc.date 2003
dc.date.accessioned 2013-05-30T11:13:13Z
dc.date.available 2013-05-30T11:13:13Z
dc.date.issued 2013-05-30
dc.identifier http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=61;epage=8;aulast=Rosenthal
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=61
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/4440
dc.description Visceral leishmaniasis (VL) is a severe disease associated with infection of the reticuloendothelial system by Leishmania species. The infection is acquired through sandfly bites. Recent large scale epidemics of VL in east Africa and India and the emergence of a HIV epidemic make VL a priority for the World Health Organization. Pentavalent antimonials have been cornerstone of treatment for the last six decades. The appearance of antimonial-resistance and the development of lipid formulations of amphotericin B have changed the pattern of VL treatment. Within the past five years, miltefosine has been demonstrated as the first effective and safe oral treatment against VL. The price of miltefosine is yet to be determined. However, miltefosine will certainly be cheaper than lipid formulations of amphotericin B, which are beyond the financial capacity of the poor countries. Because it can be administered orally, miltefosine is suited for the treatment of large number of patients who get affected during epidemics, particularly in regions where the parasites are resistant to the currently used agents. Here, we recommend different treatment schedules according to the resistance pattern and the region-specific socio-economical and cultural factors.
dc.publisher Medknow Publications
dc.source Journal of Postgraduate Medicine
dc.subject AIDS-Related Opportunistic Infections
dc.subject complications
dc.subject drug therapy
dc.subject parasitology
dc.subject Animal
dc.subject Antiprotozoal Agents
dc.subject economics
dc.subject therapeutic use
dc.subject Antiviral Agents
dc.subject economics
dc.subject therapeutic use
dc.subject Drug Resistance
dc.subject HIV Infections
dc.subject complications
dc.subject Human
dc.subject Interferon Type II
dc.subject economics
dc.subject therapeutic use
dc.subject Leishmania
dc.subject drug effects
dc.subject Leishmaniasis
dc.subject Visceral
dc.subject complications
dc.subject drug therapy
dc.subject epidemiology
dc.title Recent understanding in the treatment of visceral leishmaniasis.


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