DSpace Repository

Recent advances in the diagnosis of leishmaniasis.

Show simple item record

dc.creator Singh S
dc.creator Sivakumar R
dc.date 2003
dc.date.accessioned 2013-05-30T11:12:43Z
dc.date.available 2013-05-30T11:12:43Z
dc.date.issued 2013-05-30
dc.identifier http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=55;epage=60;aulast=Singh
dc.identifier http://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=55
dc.identifier.uri http://koha.mediu.edu.my:8181/jspui/handle/123456789/4434
dc.description Leishmaniasis is a parasitic disease caused by a haemoflagellate Leishmania. There are more than 21 species causing human infection. The infection is transmitted to humans through the bites of female sandflies belonging to 30 species. The disease manifests mainly in 3 forms: the visceral, the cutaneous and the mucocutaneous leishmaniasis. The diagnosis of visceral form is conventionally made by the demonstration of amastigotes of the parasite in the aspirated fluid from the bone marrow, the spleen, and rarely from the lymph nodes, or the liver. The parasite demonstration and isolation rates are rather poor from cutaneous and mucocutaneous lesions due to low parasite load and high rate of culture contamination. Recently several recombinant proteins have been developed to accomplish accurate diagnosis. Recombinant kinesin protein of 39 kDa called rK 39 is the most promising of these molecules. The antigen used in various test formats has been proved highly sensitive and specific for visceral leishmaniasis. It is useful in the diagnosis of HIV-Leishmania co-infection and as a prognostic marker. Molecular techniques targeting various genes of the parasite have also been reported, the PCR being the most common molecular technique successfully used for diagnosis and for differentiation of species.
dc.publisher Medknow Publications
dc.source Journal of Postgraduate Medicine
dc.subject AIDS-Related Opportunistic Infections
dc.subject diagnosis
dc.subject parasitology
dc.subject Biological Markers
dc.subject Diagnosis
dc.subject Differential
dc.subject HIV Infections
dc.subject complications
dc.subject Human
dc.subject Leishmaniasis
dc.subject diagnosis
dc.title Recent advances in the diagnosis of leishmaniasis.

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account