| dc.creator |
Das K |
|
| dc.creator |
Misra H |
|
| dc.date |
2003 |
|
| dc.date.accessioned |
2013-05-30T11:09:12Z |
|
| dc.date.available |
2013-05-30T11:09:12Z |
|
| dc.date.issued |
2013-05-30 |
|
| dc.identifier |
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2003;volume=49;issue=1;spage=17;epage=20;aulast=Das |
|
| dc.identifier |
http://www.doaj.org/doaj?func=openurl&genre=article&issn=00223859&date=2003&volume=49&issue=1&spage=17 |
|
| dc.identifier.uri |
http://koha.mediu.edu.my:8181/jspui/handle/123456789/4392 |
|
| dc.description |
BACKGROUND: Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated. AIMS: We investigated the effects of lidocaine on a postischaemic reperfused rat lung model. MATERIALS AND METHODS: Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions. RESULTS: Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs. CONCLUSION: Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung. |
|
| dc.publisher |
Medknow Publications |
|
| dc.source |
Journal of Postgraduate Medicine |
|
| dc.subject |
Animal |
|
| dc.subject |
Comparative Study |
|
| dc.subject |
Lidocaine |
|
| dc.subject |
pharmacology |
|
| dc.subject |
Lung |
|
| dc.subject |
drug effects |
|
| dc.subject |
Male |
|
| dc.subject |
Models |
|
| dc.subject |
Animal |
|
| dc.subject |
Oxygen |
|
| dc.subject |
administration & dosage |
|
| dc.subject |
Rats |
|
| dc.subject |
Rats |
|
| dc.subject |
Sprague-Dawley |
|
| dc.subject |
Reperfusion Injury |
|
| dc.subject |
prevention & control |
|
| dc.subject |
Support |
|
| dc.subject |
U.S. Gov′t |
|
| dc.subject |
P.H.S. |
|
| dc.title |
Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels. |
|