ABSTRACT: The need to implement innovative approaches to sustainability is now more critical than ever. This discussion draws on parts of the puzzle that must be assembled to achieve integrated, cross-tenure and jurisdictional management of whole regions and their peoples for a sustainable future. A regional, landscape ecology approach helps us to move on from theory and historical lessons to boldly design and adaptively develop novel on-ground models. To take an entirely different approach from conventional thinking, I draw from Common Property Resource (CPR) theory and experience, together with practical experience from the Bookmark Biosphere project. The characteristics of successful enduring Common Property regimes are identified and discussed in light of critical needs to maintain and restore social and ecological capital. I then highlight the concepts and logistical objectives behind the 30-year-old UNESCO Biosphere Reserve Program, which appears to have great potential as an operational framework within which these changes can be made. The Biosphere Reserve Program is maturing through integration of cultural needs and aspirations for quality of life, while conserving natural values and ecosystem processes. In particular, progress is being made through bioregional planning and management incorporating a variety of IUCN protected area types with novel, sustainable, resource-use diversification. The novel arrangements, experience and lessons from one developing model, Bookmark Biosphere Reserve in South Australia, are described as an example. I wish to encourage more models like the Bookmark experiment to evolve through even greater creativity and engagement with public and private partners. On-ground models that demonstrate innovative alternative land use management in the rangelands or integration across the coastal-marine interface are especially needed.