المستودع الأكاديمي جامعة المدينة

Optimal sequencing of antiretroviral drug cocktails under uncertainty and irreversibility

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dc.creator Bezabih, Mintewab
dc.creator Stolpe, Michael
dc.date 2007
dc.date.accessioned 2013-10-16T06:20:19Z
dc.date.available 2013-10-16T06:20:19Z
dc.date.issued 2013-10-16
dc.identifier http://hdl.handle.net/10419/4239
dc.identifier ppn:560065523
dc.identifier.uri http://koha.mediu.edu.my:8181/xmlui/handle/10419/4239
dc.description This paper develops a real options approach to the optimal sequencing of antiretroviral drug cocktails for HIV/AIDS patients in resource-poor settings. The analysis focuses on the implications of endogenous resistance mutations in the virus that reduce or eliminate the effectiveness of individual drugs within a cocktail when lack of laboratory equipment prevents these from being identified. Using a model with two drug cocktails, we show that the first-line therapy should be introduced later than in the case without resistance mutations and that the second-line therapy should be introduced earlier. We go on to discuss implications for comparative cost-effectiveness analyses.
dc.language eng
dc.publisher Kiel Institute for the World Economy (IfW) Kiel
dc.relation Kieler Arbeitspapiere 1371
dc.rights http://www.econstor.eu/dspace/Nutzungsbedingungen
dc.subject D81
dc.subject H51
dc.subject I12
dc.subject ddc:330
dc.subject HIV/AIDS
dc.subject Real option theory
dc.subject Cost-effectiveness analysis
dc.subject Combination therapy
dc.subject Developing countries
dc.subject AIDS
dc.subject Pharmazeutisches Produkt
dc.subject Kosten-Wirksamkeits-Analyse
dc.subject Realoption
dc.subject Entwicklungsländer
dc.title Optimal sequencing of antiretroviral drug cocktails under uncertainty and irreversibility
dc.type doc-type:workingPaper


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