We apply a multi-level approach to analyze simultaneously the effects of three groups of determinants on new firm formation: industry, location and change over time. The data is for West Germany and covers the 1983-97 period. Our analysis indicates that innovation activities and the technological regime play a significant role in new firm formation processes. There are some differences with regard to the impact of a number of variables on start-ups in manufacturing and the service sector. Changes in demand are conducive to new firm formation while a high level of unemployment in a region obviously creates a relatively uncomfortable environment for setting up new businesses.