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Nisin-controlled expression of Norwalk virus VP60 protein in Lactobacillus casei

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dc.contributor Ministerio de Ciencia y Tecnología (España)
dc.contributor European Commission
dc.contributor Fondo de Investigación Sanitaria (España)
dc.creator Martín, M. Cruz
dc.creator Fernández García, María
dc.creator Martín-Alonso, José M.
dc.creator Parra, Francisco
dc.creator Boga, José A.
dc.creator Álvarez González, Miguel Ángel
dc.date 2008-07-08T13:57:42Z
dc.date 2008-07-08T13:57:42Z
dc.date 2004-08-15
dc.date.accessioned 2017-01-31T02:43:06Z
dc.date.available 2017-01-31T02:43:06Z
dc.identifier FEMS Microbiology Letters. 237: 385-391 (2004).
dc.identifier 0378-1097
dc.identifier http://hdl.handle.net/10261/5681
dc.identifier 10.1016/j.femsle.2004.07.002
dc.identifier http://dx.doi.org/10.1016/j.femsle.2004.07.002
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5681
dc.description Final full-text version of the paper available at: http://dx.doi.org/10.1016/j.femsle.2004.07.002.
dc.description A food-grade strain with nisRK stably integrated into the genome, was constructed in order to implement the nisin-controlled expression system (NICE) in Lactobacillus casei ATCC393. Expression of β-glucuronidase (gus) reporter gene was employed to optimize the system, which has been successfully used to produce the main antigenic protein from Norwalk virus, opening new perspectives for producing edible vaccines.
dc.description This research was supported by project BIO 2002–01458 from MCYT (co-financed by the PLAN FEDER from the European Union), Project QLK1-CT-2002–02388 (European Union) and grants 01/0976 and 01/3139 from Fondo de Investigaciones Sanitarias, Spain.
dc.description Peer reviewed
dc.format 22195 bytes
dc.format application/pdf
dc.language eng
dc.publisher Elsevier
dc.publisher Federation of European Microbiological Societies
dc.rights closedAccess
dc.subject NICE system
dc.subject Antigen expression
dc.subject Norwalk virus
dc.subject Lactobacillus casei
dc.title Nisin-controlled expression of Norwalk virus VP60 protein in Lactobacillus casei
dc.type Artículo

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