DSpace Repository

Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development

Show simple item record

dc.creator Esteban, Luis Miguel
dc.creator Fernández-Medarde, Alberto
dc.creator López, Eva
dc.creator Tessarollo, Lino
dc.creator Santos de Dios, Eugenio
dc.creator Guerrero Arroyo, María del Carmen
dc.date 2008-06-17T12:13:34Z
dc.date 2008-06-17T12:13:34Z
dc.date 2000-09
dc.date.accessioned 2017-01-31T01:42:46Z
dc.date.available 2017-01-31T01:42:46Z
dc.identifier Molecular and Cellulr Biology 20(7): 6410–6413 (2000)
dc.identifier 0270-7306
dc.identifier http://hdl.handle.net/10261/5144
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/5144
dc.description The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in transmission of signals initiated by surface protein tyrosine kinases that are transduced into the cell through the action of membrane-associated Ras proteins. Recent reports showed that targeted disruption of the sos1 locus results in embryonic lethality. To gain insight into the in vivo function of sos2, we disrupted its catalytic CDC25-H domain by means of gene targeting techniques. Mating among heterozygous sos2+/− mice produced viable sos2−/− offspring with a normal Mendelian pattern of inheritance, indicating that the loss of sos2 does not interfere with embryo viability in the uterus. Adult homozygous mutant sos2−/− mice reached sexual maturity at the same age as their wild-type littermates, and both male and female null mutants were fertile. Histopathological analysis showed no observable differences between mutant and wild-type mice. Our results show that unlike the case for sos1, sos2 gene function is dispensable for normal mouse development, growth, and fertility.
dc.description Peer reviewed
dc.format 25089 bytes
dc.format application/pdf
dc.language eng
dc.publisher American Society for Microbiology
dc.relation http://mcb.asm.org/cgi/reprint/20/17/6410
dc.rights closedAccess
dc.title Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
dc.type Artículo

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account