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Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

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dc.creator Courtine, Grégoire
dc.creator Bunge, Mary Bartlett
dc.creator Fawcett, James W.
dc.creator Grossman, Robert G.
dc.creator Kaas, Jon H.
dc.creator Lemon, Roger
dc.creator Maier, Irin
dc.creator Martin, John
dc.creator Nudo, Randolph J.
dc.creator Ramón-Cueto, Almudena
dc.creator Rouiller, Eric M.
dc.creator Schnell, Lisa
dc.creator Wannier, Thierry
dc.creator Schwab, Martin E.
dc.creator Edgerton, V. Reggie
dc.date 2008-06-10T10:22:37Z
dc.date 2008-06-10T10:22:37Z
dc.date 2007-05
dc.date.accessioned 2017-01-31T01:37:59Z
dc.date.available 2017-01-31T01:37:59Z
dc.identifier Nat Med. 2007 May;13(5):561-566
dc.identifier http://hdl.handle.net/10261/4941
dc.identifier 10.1038/nm1583
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4941
dc.description The definitive version is available at http://www.nature.com/nm/journal/v13/n5/pdf/nm1595.pdf
dc.description Progress continues in developing reparative interventions to enhance recovery after experimental spinal cord injury (SCI). Much of the progress has been made with rodents, but they differ in some important ways from humans and other primates in size, neuroanatomy, neurophysiology, physiology, biochemistry, immunology, and behavior. Questions discussed were to what extent SCI rodent models present limitations for ensuring the efficacy and safety of a treatment for humans, and under what circumstances it would be advantageous or necessary to test treatments in non-human primates before or as an adjunct to clinical trials in human patients. We focus on the recovery of skilled motor control, which enables us to compare and contrast the known differences in the organization of the motor systems and in the behavior among rodents, non-human primates, and humans. In addition, we point out critical issues related to safety in the context of promoting neural connections after an injury that could lead to malfunction. Non-human primates and humans share a myriad of similarities between the structure of their motor systems and motor behavior. Therefore, the non-human primate SCI model provides many unique advantages for testing experimental effects and understanding the safeness of a reparative intervention to promote functional recovery following SCI with the appropriate relevance for humans. We conclude that non-human primate studies are critical for the timely and safe translation of selected potential interventions designed to repair neuromotor impairments in humans.
dc.description This paper summarizes the discussions that took place in a workshop sponsored and organized by the Christopher Reeve Foundation (CRF).
dc.description Peer reviewed
dc.format 95958 bytes
dc.format application/pdf
dc.language eng
dc.publisher Nature Publishing Group
dc.rights openAccess
dc.title Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
dc.type Artículo

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