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Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models

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dc.creator Martín-Sanz, Paloma
dc.creator Hortelano, Sonsoles
dc.creator Boscá, Lisardo
dc.creator Casado, Marta
dc.date 2008-06-09T11:05:53Z
dc.date 2008-06-09T11:05:53Z
dc.date 2006-09-01
dc.date.accessioned 2017-01-31T01:36:32Z
dc.date.available 2017-01-31T01:36:32Z
dc.identifier Frontiers in Bioscience 11: 2876-2878 (2006)
dc.identifier 1093-9946
dc.identifier http://hdl.handle.net/10261/4903
dc.identifier 10.2741/2016
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4903
dc.description El pdf del artículo es la versión post-print.
dc.description Cyclooxygenase (COX) -1 and –2 catalyze the first step in the biosynthesis of prostanoids. COX-1 is constitutively expressed in many tissues and seems to be involved in the house keeping function of prostanoids. COX-2, the inducible isoform, accounts for the elevated production of prostaglandins in response to various inflammatory stimuli, hormones and growth factors. COX-2 expression has been also associated with cell growth regulation, tissue remodelling and carcinogenesis. More of these characteristics have been elucidate through using COX selective inhibitors. Recent advances in transgenic and gene-targeting approaches allow a sophisticated manipulation of the mouse genome by gene addition, gene deletion or gene modifications. The development of COX-2 genetically altered mice has provided models to elucidate the physiological and pathophysiological roles of this enzyme.
dc.description This work was supported by grants from Instituto de Salud Carlos III (Red de Centros C03/01), Generalitat Valenciana (GRUPOS03/072), Ministerio de Educación y Ciencia (SAF2004-00957) and Comunidad de Madrid (CAM2004-GR/SAL/0388).
dc.description Peer reviewed
dc.format 256850 bytes
dc.format application/pdf
dc.language eng
dc.publisher Frontiers in Bioscience Publications
dc.relation Postprint
dc.relation http://dx.doi.org/10.2741/2016
dc.rights openAccess
dc.subject Cyclooxygenase
dc.subject Prostanoids
dc.title Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models
dc.type Artículo

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