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A message emerging from development: the repression of mitochondrial β-F1-ATPase expression in cancer

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dc.contributor Ministerio de Sanidad y Consumo (España)
dc.contributor Ministerio de Educación y Ciencia (España)
dc.contributor Fundación Mutua Madrileña
dc.contributor Fundación Ramón Areces
dc.creator Cuezva, José M.
dc.creator Sánchez-Aragó, María
dc.creator Sala, Sandra
dc.creator Blanco-Rivero, Amaya
dc.creator Ortega, Álvaro D.
dc.date 2008-06-05T14:23:01Z
dc.date 2008-06-05T14:23:01Z
dc.date 2007-08-28
dc.date.accessioned 2017-01-31T01:34:50Z
dc.date.available 2017-01-31T01:34:50Z
dc.identifier Journal of Bioenergetics & Biomembranes Vol.39 (3) 259-265 (2007)
dc.identifier 0145-479X (Print)
dc.identifier 1573-6881 (Online)
dc.identifier http://hdl.handle.net/10261/4822
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4822
dc.description The original publication is available at www.springerlink.com http://dx.doi.org/10.1007/s10863-007-9087-9
dc.description Mitochondrial research has experienced a considerable boost during the last decade because organelle malfunctioning is in the genesis and/or progression of a vast array of human pathologies including cancer. The renaissance of mitochondria in the cancer field has been promoted by two main facts: (1) the molecular and functional integration of mitochondrial bioenergetics with the execution of cell death and (2) the implementation of 18FDG-PET for imaging and staging of tumors in clinical practice. The latter, represents the bed-side translational development of the metabolic hallmark that describes the bioenergetic phenotype of most cancer cells as originally predicted at the beginning of previous century by Otto Warburg. In this minireview we will briefly summarize how the study of energy metabolism during liver development forced our encounter with Warburg’s postulates and prompted us to study the mechanisms that regulate the biogenesis of mitochondria in the cancer cell
dc.description This review article was written while the research activity in the authors’ laboratory was supported by grants from the Ministerio de Sanidad (PI041255), Educación y Ciencia (SAF2005-4001) and Fundación Mutua Madrileña. The CBMSO is the recipient of an institutional grant from Fundación Ramón Areces
dc.description Peer reviewed
dc.format 228887 bytes
dc.format application/pdf
dc.language eng
dc.publisher Springer
dc.rights openAccess
dc.subject Mitochondria
dc.subject H+-ATP synthase
dc.subject Oxidative phosphorylation
dc.subject Glycolysis
dc.subject Cancer
dc.title A message emerging from development: the repression of mitochondrial β-F1-ATPase expression in cancer
dc.type Artículo

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