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A conserved mechanism of Hedgehog gradient formation by lipid modifications

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dc.contributor Ministerio de Economía y Competitividad (España)
dc.contributor Fundación Ramón Areces
dc.contributor National Institutes of Health (US)
dc.contributor March of Dimes Foundation
dc.creator Guerrero Vega, Isabel
dc.creator Chiang, Chin
dc.date 2008-06-04T14:45:56Z
dc.date 2008-06-04T14:45:56Z
dc.date 2006-11-28
dc.date.accessioned 2017-01-31T01:34:11Z
dc.date.available 2017-01-31T01:34:11Z
dc.identifier Trends in Cell Biology Vol.17, Issue 1, January 2007, Pages 1-5
dc.identifier 0962-8924 (Print)
dc.identifier http://hdl.handle.net/10261/4802
dc.identifier 10.1016/j.tcb.2006.11.002
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4802
dc.description Members of the Hedgehog (Hh) family of proteins are conserved morphogens that modulate cell fates in target tissues in different developmental systems. Dysregulation of Hh signaling results in a wide range of human diseases. The mature Hh is modified by lipids in two places, with palmitate at the N-terminus and cholesterol at the C-terminus. The lipid modifications are essential to the proper secretion and spreading of the morphogen throughout the extracellular matrix, interacting with heparan sulfate proteoglycans. However, the role of lipid modifications in regulating the range and activity of Hh proteins remains controversial. Here, we aim to resolve this issue by providing a model that is consistent with current and past reports. We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space
dc.description We also thank the support of the Spanish D.G.I.C.Y.T, grant BFU2005-04183 (I.G.), the Fundación Areces for an institutional grant (I.G.), National Institutes of Health grant HD049667 (C.C.) and March of Dimes foundation (C.C)
dc.description Peer reviewed
dc.format 54791 bytes
dc.format application/pdf
dc.language eng
dc.publisher Elsevier
dc.relation http://dx.doi.org/10.1016/j.tcb.2006.11.002
dc.rights openAccess
dc.subject Drosophila
dc.subject Hedgehog
dc.title A conserved mechanism of Hedgehog gradient formation by lipid modifications
dc.type Artículo

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