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The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila

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dc.contributor Ministerio de Economía y Competitividad (España)
dc.contributor Fundación Ramón Areces
dc.creator Molnar, Cristina
dc.creator Holguín, Helena
dc.creator Mayor Menéndez, Federico
dc.creator Ruiz-Gómez, Ana
dc.creator Celis, José F. de
dc.date 2008-06-03T15:28:55Z
dc.date 2008-06-03T15:28:55Z
dc.date 2007-05-01
dc.date.accessioned 2017-01-31T01:33:39Z
dc.date.available 2017-01-31T01:33:39Z
dc.identifier PNAS | May 8, 2007 | vol. 104 | no. 19 | 7963-7968
dc.identifier 0027-8424 (Print)
dc.identifier 1091-6490 (Online)
dc.identifier http://hdl.handle.net/10261/4785
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4785
dc.description Article available at http.//dx.doi.org/10.1073/pnas.0702374104
dc.description Signaling by Smoothened (Smo) plays fundamental roles during animal development and is deregulated in a variety of human cancers. Smo is a transmembrane protein with a heptahelical topology characteristic of G protein-coupled receptors. Despite such similarity, the mechanisms regulating Smo signaling are not fully understood. We show that Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo signal transduction pathway. Lowering Gprk2 levels in the wing disc reduces the expression of Smo targets and causes a phenotype reminiscent of loss of Smo function. We found that Gprk2 function is required for transducing the Smo signal and that when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Interestingly, the expression of Gprk2 in the wing disc is regulated in part by Smo, generating a positive feedback loop that maintains high Smo activity close to the anterior–posterior compartment boundary
dc.description This work was supported by Dirección General de Investigación Científica y Técnica Grants BCM2003-1191 and GEN2001-4846-C05-01 (to J.F.d.C.) and SAF2005-03053 (to F.M.) and an institutional grant from Fundación Ramón Areces to the Centro de Biología Molecular "Severo Ochoa."
dc.description Peer reviewed
dc.format 2080056 bytes
dc.format application/pdf
dc.language eng
dc.publisher National Academy of Sciences (U.S.)
dc.rights openAccess
dc.subject Smoothened
dc.subject Wing disc
dc.subject Imaginal discs
dc.title The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
dc.type Artículo


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