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Antimicrobial properties of derivatives of the cationic tryptophan-rich hexapeptide PAF26

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dc.creator Muñoz, Alberto
dc.creator López García, Belén
dc.creator Pérez-Payá, Enrique
dc.creator Marcos López, José Francisco
dc.date 2008-05-19T07:49:40Z
dc.date 2008-05-19T07:49:40Z
dc.date 2007-03
dc.date.accessioned 2017-01-31T01:21:34Z
dc.date.available 2017-01-31T01:21:34Z
dc.identifier Biochem Biophys Res Commun 354 (1): 172-177
dc.identifier http://hdl.handle.net/10261/4324
dc.identifier 10.1016/j.bbrc.2006.12.173
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4324
dc.description The definitive version is available at http://www.sciencedirect.com/science/journal/0006291X
dc.description Short antimicrobial peptides represent an alternative to fight pathogen infections. PAF26 is a hexapeptide identified previously by a combinatorial approach against the fungus Penicillium digitatum and shows antimicrobial properties towards certain phytopathogenic fungi. In this work, PAF26 was used as lead compound and its properties were compared with two series of derivatives, obtained by either systematic alanine substitution or N-terminal amino acid addition. The alanine scan approach underlined the optimized sequence of PAF26 in terms of potency and permeation capability, and also the higher contribution of the cationic residues to these properties. The N-terminal addition of amino acids resulted in new heptapeptides with variations in their antimicrobial characteristics, and very low cytolysis to human red blood cells. Positive (Arg or Lys) and aromatic (Phe or Trp) residue addition increased broad spectrum activity of PAF26. Noteworthy, addition of selected residues had specific effects on the properties of derivatives of PAF26.
dc.description Work was supported by grants BIO2003-00927 and BIO2006-09523 from the Spanish Ministry of Education and Science (MEC). B.L.-G. acknowledges the post doctoral program “Juan de la Cierva” of the Spanish MEC.
dc.description Peer reviewed
dc.format 863841 bytes
dc.format application/pdf
dc.language eng
dc.publisher Elsevier
dc.relation http://dx.doi.org/10.1016/j.bbrc.2006.12.173
dc.rights openAccess
dc.subject Tryptophan-rich cationic antimicrobial peptide
dc.subject AMP
dc.subject Antifungal peptide
dc.subject Phytopathogenic fungi
dc.subject P. digitatum
dc.subject B. cinerea
dc.subject M. grisea
dc.subject F. oxysporum
dc.title Antimicrobial properties of derivatives of the cationic tryptophan-rich hexapeptide PAF26
dc.type Artículo

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