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Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit

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dc.creator Badimón, Juan José
dc.creator Badimón, Lina
dc.creator Fuster, Valentín
dc.date 2008-05-09T11:58:35Z
dc.date 2008-05-09T11:58:35Z
dc.date 1990-04
dc.date.accessioned 2017-01-31T01:13:22Z
dc.date.available 2017-01-31T01:13:22Z
dc.identifier J Clin Invest. 85(4): 1234–1241 (1990).
dc.identifier 0021-9738
dc.identifier http://hdl.handle.net/10261/4123
dc.identifier 10.1172/JCI114558
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4123
dc.description PMCID: PMC296557
dc.description The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich diet for 60 d (group 1). Another group of animals were maintained on the same diet for 90 d (group 2). A third group was also fed the same diet for 90 d but received 50 mg HDL-VHDL protein per wk (isolated from normolipemic rabbit plasma) during the last 30 d (group 3). Aortic atherosclerotic involvement at the completion of the study was 34 ± 4% in group 1, 38.8 ± 5% in group 2, and 17.8 ± 4% in group 3 (P < 0.005). Aortic lipid deposition was also significantly reduced in group 3 compared with group 1 (studied at only 60 d) and group 2. This is the first in vivo, prospective evidence of the antiatherogenic effect of HDLVHDL against preexisting atherosclerosis. Our results showed that HDL plasma fractions were able to induce regression of established aortic fatty streaks and lipid deposits. Our results suggest that it may be possible not only to inhibit progression but even to reduce established atherosclerotic lesions by HDL administration.
dc.description This work was supported by National Institutes of Health grant HL-39840 and by funds from a Heart Research Foundation grant.
dc.description Peer reviewed
dc.format 2400562 bytes
dc.format application/pdf
dc.language eng
dc.publisher American Society for Clinical Investigation
dc.rights openAccess
dc.subject Atherosclerosis
dc.subject Cholesterol-fed rabbit
dc.subject HDL-VHDL
dc.subject Regression
dc.subject Lipoprotein
dc.title Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
dc.type Artículo


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