| dc.creator |
Cortés-Ledesma, Felipe |
|
| dc.creator |
Piccoli, Giaccomo de |
|
| dc.creator |
Haber, James E. |
|
| dc.creator |
Aragón, Luis |
|
| dc.creator |
Aguilera, Andrés |
|
| dc.date |
2008-05-08T16:09:12Z |
|
| dc.date |
2008-05-08T16:09:12Z |
|
| dc.date |
2007-04-15 |
|
| dc.date.accessioned |
2017-01-31T01:12:39Z |
|
| dc.date.available |
2017-01-31T01:12:39Z |
|
| dc.identifier |
Cell Cycle 6(8): 914-918 (2007) |
|
| dc.identifier |
1538-4101 (Print) |
|
| dc.identifier |
1551-4005 (Online) |
|
| dc.identifier |
http://hdl.handle.net/10261/4097 |
|
| dc.identifier |
10.4161/cc.6.8.4107 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4097 |
|
| dc.description |
PMID: 17404505.-- Previously published online as a Cell Cycle E-publication:
http://www.landesbioscience.com/journals/cc/abstract.php?id=4107 |
|
| dc.description |
Homologous recombination (HR) is one of the key mechanisms responsible for the repair of DNA double-strand breaks (DSBs), including those that occur during DNA replication. Recent studies in yeast and mammals have uncovered that the SMC complexes cohesins and Smc5-Smc6 are recruited to induced DSBs, and play a role in the maintenance of genome stability by favouring SCR as the main recombinational DSB repair mechanism. These new results raise intriguing questions such as whether SMC proteins might play a functional role at collapsed replication forks, which may represent the main source of spontaneous recombinogenic damage. A deeper knowledge of the role of SMC proteins in DSB repair should contribute to a better understanding of chromosome dynamics and stability. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
21663 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Landes Bioscience |
|
| dc.relation |
http://dx.doi.org/10.4161/cc.6.8.4107 |
|
| dc.rights |
openAccess |
|
| dc.subject |
Sister chromatid exchange |
|
| dc.subject |
Double-strand break repair |
|
| dc.subject |
Homologous Recombination |
|
| dc.subject |
Break-induced replication |
|
| dc.subject |
Collapsed replication forks |
|
| dc.subject |
Cohesins |
|
| dc.subject |
MRX/MRN complex |
|
| dc.subject |
Smc5-Smc6 |
|
| dc.subject |
SMC complexes |
|
| dc.title |
SMC proteins, new players in the maintenance of genomic stability |
|
| dc.type |
Artículo |
|