| dc.creator |
Aguilera, Andrés |
|
| dc.creator |
Gómez-González, Belén |
|
| dc.date |
2008-05-08T15:17:30Z |
|
| dc.date |
2008-05-08T15:17:30Z |
|
| dc.date |
2008-03 |
|
| dc.date.accessioned |
2017-01-31T01:12:32Z |
|
| dc.date.available |
2017-01-31T01:12:32Z |
|
| dc.identifier |
Nature Reviews Genetics 9: 204-217 (2008) |
|
| dc.identifier |
1471-0056 |
|
| dc.identifier |
http://hdl.handle.net/10261/4094 |
|
| dc.identifier |
10.1038/nrg2268 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4094 |
|
| dc.description |
14 páginas, 6 figuras, 1 tabla. PMID: 18227811.-- Final full-text version of the paper available at: http://dx.doi.org/10.1038/nrg2268.-- Supplementary material available at: http://www.nature.com/nrg/journal/v9/n3/extref/nrg2268-s1.pdf |
|
| dc.description |
Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability -among them are replication, repair and S-phase checkpoint factors- and those that act in cis -chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability. |
|
| dc.description |
Research in A.A.’s laboratory is funded by grants from the Spanish Ministry of Science and Education (BFU2006‑05260), Consolider Ingenio 2010 (CDS2007‑015) and Junta de Andalucía (CVI102 and CVI624). |
|
| dc.description |
Peer reviewed |
|
| dc.format |
22195 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Nature Publishing Group |
|
| dc.relation |
http://dx.doi.org/10.1038/nrg2268 |
|
| dc.rights |
closedAccess |
|
| dc.subject |
Genomic instability |
|
| dc.subject |
Mutations |
|
| dc.subject |
Mechanics |
|
| dc.title |
Genome instability: a mechanistic view of its causes and consequences |
|
| dc.type |
Artículo |
|