المستودع الأكاديمي جامعة المدينة

Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton

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dc.creator Bolívar, Jorge
dc.creator Huynh, Jean-René
dc.creator López-Schier, Hernán
dc.creator González, Cayetano
dc.creator St Johnston, Daniel
dc.creator González-Reyes, Acaimo
dc.date 2008-05-07T16:30:17Z
dc.date 2008-05-07T16:30:17Z
dc.date 2001-04-19
dc.date.accessioned 2017-01-31T01:11:47Z
dc.date.available 2017-01-31T01:11:47Z
dc.identifier Development 128, 1889-1909 (2001).
dc.identifier 0950-1991
dc.identifier http://hdl.handle.net/10261/4078
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4078
dc.description During early Drosophila oogenesis, one cell from a cyst of 16 germ cells is selected to become the oocyte, and accumulates oocyte-specific proteins and the centrosomes from the other 15 cells. Here we show that the microtubule cytoskeleton and the centrosomes follow the same stepwise restriction to one cell as other oocyte markers. Surprisingly, the centrosomes still localise to one cell after colcemid treatment, and in BicD and egl mutants, which abolish the localisation of all other oocyte markers and the polarisation of the microtubule cytoskeleton. In contrast, the centrosomes fail to migrate in cysts mutant for Dynein heavy chain 64C, which disrupts the fusome. Thus, centrosome migration is independent of the organisation of the microtubule cytoskeleton, and seems to depend instead on the polarity of the fusome.
dc.description Peer reviewed
dc.format 1101419 bytes
dc.format application/pdf
dc.language eng
dc.publisher Company of Biologists
dc.rights openAccess
dc.subject Drosophila oogenesis
dc.subject Oocyte determination
dc.subject Fusome
dc.subject Microtubule
dc.subject Centrosome
dc.title Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton
dc.type Artículo


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