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Integrin Signaling Regulates Spindle Orientation in Drosophila to Preserve the Follicular-Epithelium Monolayer

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dc.creator Fernández-Miñán, Ana
dc.creator Martín-Bermudo, María D.
dc.creator González-Reyes, Acaimo
dc.date 2008-05-07T12:55:15Z
dc.date 2008-05-07T12:55:15Z
dc.date 2007-04-17
dc.date.accessioned 2017-01-31T01:11:33Z
dc.date.available 2017-01-31T01:11:33Z
dc.identifier Current Biology 17(8): 683-688 (2007)
dc.identifier 0960-9822
dc.identifier PMID: 17363255
dc.identifier http://hdl.handle.net/10261/4070
dc.identifier 10.1016/j.cub.2007.02.052
dc.identifier 1879-0445
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4070
dc.description Epithelia act as important physiological barriers and as structural components of tissues and organs. In the Drosophila ovary, follicle cells envelop the germline cysts to form a monolayer epithelium. During division, the orientation of the mitotic spindle in follicle cells is such that both daughter cells remain within the same plane, and the simple structure of the follicular epithelium is thus preserved. Here we show that integrins, heterodimeric transmembrane receptors that connect the extracellular matrix to the cell's cytoskeleton 1 and 2, are required for maintaining the ovarian monolayer epithelium in Drosophila. Mosaic egg chambers containing integrin mutant follicle cells develop stratified epithelia at both poles. This stratification is due neither to abnormal cell proliferation nor to defects in the apical-basal polarity of the mutant cells. Instead, integrin function is required for the correct orientation of the mitotic apparatus both in mutant cells and in their immediately adjacent wild-type neighbors. We further demonstrate that integrin-mediated signaling, rather than adhesion, is sufficient for maintaining the integrity of the follicular epithelium. The above data show that integrins are necessary for preserving the simple organization of a specialized epithelium and link integrin-mediated signaling to the correct orientation of the mitotic spindle in this epithelial cell type.
dc.description Research in our laboratories is funded by the Spanish Ministerio de Ciencia y Tecnología (BMC2003-01512 and BFU2006-10934 to A. G-R; BMC2001-2298 and BFU2004-02840/BMC to M.D.M.-B.), by the European Molecular Biology Organization Young Investigator Programme, and by the Junta de Andalucía (CVI-280). A.F.-M. was supported by a Formación de Personal Investigador studentship from the Spanish Ministerio de Ciencia y Tecnología and by an I3P-Consejo Superior de Investigaciones Cientificas contract.
dc.description Peer reviewed
dc.format 22195 bytes
dc.format application/pdf
dc.language eng
dc.publisher Elsevier
dc.relation http://dx.doi.org/10.1016/j.cub.2007.02.052
dc.rights closedAccess
dc.subject Cellular Biology
dc.subject Signaling
dc.subject Development Biology
dc.subject Drosophila
dc.subject Epithelium
dc.subject Ovarian follicle
dc.title Integrin Signaling Regulates Spindle Orientation in Drosophila to Preserve the Follicular-Epithelium Monolayer
dc.type Artículo


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