المستودع الأكاديمي جامعة المدينة

Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis

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dc.creator Jiménez, Gerardo
dc.creator González-Reyes, Acaimo
dc.creator Casanova, Jordi
dc.date 2008-05-06T16:19:30Z
dc.date 2008-05-06T16:19:30Z
dc.date 2002-04-15
dc.date.accessioned 2017-01-31T01:11:04Z
dc.date.available 2017-01-31T01:11:04Z
dc.identifier Genes and Development 16(8): 913–918 (2002)
dc.identifier 0890-9369
dc.identifier PMCID: PMC152353
dc.identifier http://hdl.handle.net/10261/4049
dc.identifier 10.1101/gad.223902
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/4049
dc.description 6 páginas, 4 figuras.
dc.description Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of the eggshell, and act in the Torso RTK signaling pathway that specifies the terminal regions of the embryo. Nasrat and Polehole are essential for extracellular accumulation of Torso-like, a factor secreted during oogenesis that initiates Torso receptor activation. Stabilization of secreted factors by specialized pericellular proteins may be a general mechanism during signaling and developmental patterning.
dc.description G.J. was supported by a contract from the Spanish Ministerio de Educación y Cultura (MEC). This work was funded by the Spanish MEC and the Generalitat de Catalunya (C.R. Biotecnologia).
dc.description This work was funded by the Spanish MEC and the Generalitat de Catalunya (CR Biotecnologia).
dc.description Peer reviewed
dc.format 509297 bytes
dc.format application/pdf
dc.language eng
dc.publisher Cold Spring Harbor Laboratory. Press
dc.relation http://dx.doi.org/10.1101/gad.223902
dc.rights closedAccess
dc.subject Drosophila
dc.subject Oncogenesis
dc.subject Intercellular signaling events
dc.subject Nasrat protein
dc.subject Polehole protein
dc.title Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis
dc.type Artículo


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