| dc.creator |
Ramos, Juan L. |
|
| dc.creator |
Rojo, Fernando |
|
| dc.creator |
Zhou, L. |
|
| dc.creator |
Timmis, K. N. |
|
| dc.date |
2008-04-23T12:17:38Z |
|
| dc.date |
2008-04-23T12:17:38Z |
|
| dc.date |
1990-04-25 |
|
| dc.date.accessioned |
2017-01-31T01:03:14Z |
|
| dc.date.available |
2017-01-31T01:03:14Z |
|
| dc.identifier |
Nucleic Acids Research 18(8): 2149–2152 (1990) |
|
| dc.identifier |
0305-1048 |
|
| dc.identifier |
http://hdl.handle.net/10261/3700 |
|
| dc.identifier |
10.1093/nar/18.8.2149 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3700 |
|
| dc.description |
Final full-text version of the paper available at: http://nar.oxfordjournals.org/cgi/content/abstract/18/8/2149 .-- Copyright © by Oxford University Press. -- Http://nar.oxfordjournals.org/ |
|
| dc.description |
The XylS family consists of at least 8 different
transcriptional regulators. Six of these proteins are
positive regulators for the catabolism of carbon sources
(benzoate and sugars) in Escherichia coli,
Pseudomonas putida and Erwinia carotovora, and two
of them are involved in pathogenesis in Escherichia coli
and Yersinia enterocolitica. Based on protein
alignments, the members of this family exhibit a long
stretch of homology at the C-terminal end. The
regulators involved in the catabolism of carbon sources
stimulate transcription from their respectively regulated
promoters only in the presence of effectors. In two of
the regulators, mutations at the non-homologous Nterminus
alter affinity and specificity for effectors while
mutations at the conserved C-terminus part decrease
activation of transcription from their corresponding
regulated promoters. It is thus probable that the
variable N-terminus end in this family of regulators
contains the motif involved in effector recognition,
while the C-terminal end is involved in DNA-binding.
These proteins seem to be related by common ancestry
and may act through similar mechanisms of positive
regulation effected through similar folding patterns. |
|
| dc.description |
Work in Granada was supported by a grant from the Comision Interministerial de Ciencia y Tecnologia (BT0023/87) to J.L.R.; L.Z. was supported by a post-doctoral fellowship from the Spanish Ministry of Education and F.R. is a post-doctoral fellow of the Juan March Foundation. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
22195 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Oxford University Press |
|
| dc.relation |
http://dx.doi.org/10.1093/nar/18.8.2149 |
|
| dc.rights |
openAccess |
|
| dc.title |
A family of positive regulators related to the pseudomonas putida TOL plasmid XylS and the Escherichia coli AraC activators |
|
| dc.type |
Artículo |
|