| dc.creator |
Bárcena, Alicia |
|
| dc.creator |
Toribio, María Luisa |
|
| dc.creator |
Pezzi, Luis |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.date |
2008-04-23T10:36:07Z |
|
| dc.date |
2008-04-23T10:36:07Z |
|
| dc.date |
1990-08 |
|
| dc.date.accessioned |
2017-01-31T01:03:10Z |
|
| dc.date.available |
2017-01-31T01:03:10Z |
|
| dc.identifier |
The Journal of Experimental Medicine, Volume 172, August 1990, pp. 439-446 |
|
| dc.identifier |
0022-1007 |
|
| dc.identifier |
http://hdl.handle.net/10261/3692 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3692 |
|
| dc.description |
El copyright pertenece a The Rockefeller University Press |
|
| dc.description |
We have analyzed the effect of human recombinant interleukin 4 (rIL4) on the growth and differentiation of human intrathymic pre-T cells (CD7+2+1-3-4-8-) . We describe that this population of T cell precursors proliferates in response to rIL4 (in the absence of mitogens or other stimulatory signals) in a dose-dependent way. The IL-4-induced proliferation is independent of the IL-2 pathway, as it cannot be inhibited with an anti-IL2 receptor a chain antibody. In our
culture conditions, rIL4 also promotes the differentiation of preT cells into phenotypically mature T cells. Although both CD3/T cell receptor (TCR)-[alfa/beta]+ and CD3-[gamma/delta]+ T cells were obtained,the preferential differentiation into TCR-y/a+ cells was a consistent finding. These results suggest that, in addition to IL-2, IL4 plays a critical role in promoting growth and differentiation of intrathymic T cell precursors at early stages of T cell development |
|
| dc.description |
Peer reviewed |
|
| dc.format |
917864 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.rights |
openAccess |
|
| dc.title |
Role for interleukin 4 in the differentiation of mature T cell receptor [gamma/delta]+ cells from human intrathymic T cell precursors |
|
| dc.type |
Artículo |
|