| dc.creator |
Hera, Antonio de la |
|
| dc.creator |
Marcos, Miguel A. R. |
|
| dc.creator |
Toribio, María Luisa |
|
| dc.creator |
Márquez, Carlos |
|
| dc.creator |
Gaspar, Maria Luisa |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.date |
2008-04-22T12:11:56Z |
|
| dc.date |
2008-04-22T12:11:56Z |
|
| dc.date |
1987-09 |
|
| dc.date.accessioned |
2017-01-31T01:03:03Z |
|
| dc.date.available |
2017-01-31T01:03:03Z |
|
| dc.identifier |
The Journal of Experimental Medicine, Vol. 166, Septembre (1987), pp. 804-809 |
|
| dc.identifier |
0022-1007 |
|
| dc.identifier |
http://hdl.handle.net/10261/3678 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3678 |
|
| dc.description |
El copyright pertenece a The Rockefeller University Press |
|
| dc.description |
Developmental analyses of B cell differentiation are consistent with the existence of at least two distinct lineages . Thus, adult bone marrow solely regenerates the commonest (Ly-1 -) lineage, while Ly-1 + B cells reconstitute the Ly-1 + B cell lineage (1). CBA/N mice carrying the X-linked immunodeficiency gene (xid)
show a defective differentiation of B lymphocytes (2) . They lack all Ly-1 + B cells as well as the normally predominant subpopulation within the Ly-1 - lineage (3) .
Functional studies (4) indicated that Ly-1 + B cells are responsible for the production
of most of the autoantibodies, while those B cells in the Ly-1 - lineage
participate in the conventional responses to "foreign" antigens. These observations
may account for both the protection conferred against autoimmune disease,
when the xid genetic defect is bred into lupus-prone strains, and the CBA/N
mice unresponsiveness to many bacterial antigens (5, 6) .
Administration of the immunosuppressant cyclosporine A (CsA) at the time of
autologous bone marrow reconstitution results in systemic autoimmunity in
CBA/N mice. Besides, these mice show a severe diminution, if not absence, of
bone marrow pre-B cells, but increased amounts of activated B cells and autoantibodies (7). We have now studied the possibility that Ly-1 + B cell precursors
may exist in CBA/N mice and report here experiments indicating that this is indeed the case |
|
| dc.description |
Peer reviewed |
|
| dc.format |
392959 bytes |
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| dc.format |
application/pdf |
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| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.rights |
openAccess |
|
| dc.title |
Development of Ly-1+ B Cells in immunodeficient CBA/N mice |
|
| dc.type |
Artículo |
|