| dc.creator |
Bernabé, Rosa R. |
|
| dc.creator |
Coutinho, Antonio |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.creator |
Cazenave, Pierre-André |
|
| dc.date |
2008-04-22T11:54:04Z |
|
| dc.date |
2008-04-22T11:54:04Z |
|
| dc.date |
1981-08 |
|
| dc.date.accessioned |
2017-01-31T01:03:00Z |
|
| dc.date.available |
2017-01-31T01:03:00Z |
|
| dc.identifier |
The Journal of Experimental Medicine, Volume 154, August 1981, pp. 552-556 |
|
| dc.identifier |
0022-1007 |
|
| dc.identifier |
http://hdl.handle.net/10261/3677 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3677 |
|
| dc.description |
El copyright pertenece a The Rockefeller University Press |
|
| dc.description |
The network theory of the immune system can be reduced to the interactions
between soluble and cell-bound idiotypes and combining sites, independently of the
functional properties of the lymphocytes bearing those elements . After its original
exposition, however, much attention has been drawn to the functionally opposing
consequences of the activity mediated by distinct classes of lymphocytes. The "plusminus" general network interactions have thus been progressively substituted by "mini-networks" of suppressor and helper T cells, often disconnected from the overall
regulatory influences maintaining steady states in a complete, and therefore circular, repertoire .
It appeared important, therefore, to establish a primary, quantitative description of the immune elements in various steady states to provide the basis for a description of immune networks . This, on the other hand, would perhaps contribute to resolving the present problems of predicting pathways in network interactions and the consequences
of specific manipulations . We have initiated these attempts by determining
B cell precursor frequencies in quantitative assays , under conditions that limit only for the clonal precursor itself. This was done in a well-characterized system
prototype of network regulation using monoclonal idiotypes and anti-idiotypes |
|
| dc.description |
Peer reviewed |
|
| dc.format |
283947 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.rights |
openAccess |
|
| dc.title |
Immune networks : frequencies of antibody and idiotype producing B cell clones in various steady states |
|
| dc.type |
Artículo |
|