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Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation

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dc.creator Jia, Gui-Quan
dc.creator Gonzalo, José Ángel
dc.creator Lloyd, Clare M.
dc.creator Kremer, Leonor
dc.creator Lu, Lei
dc.creator Martínez-Alonso, Carlos
dc.creator Wershill, B.K.
dc.creator Gutiérrez Ramos, José Carlos
dc.date 2008-04-16T12:31:38Z
dc.date 2008-04-16T12:31:38Z
dc.date 1996-11
dc.date.accessioned 2017-01-31T01:02:27Z
dc.date.available 2017-01-31T01:02:27Z
dc.identifier The Journal of Experimental Medicine, Volume 184, November 1996 , pp.1939-1951
dc.identifier 0022-1007
dc.identifier http://hdl.handle.net/10261/3624
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3624
dc.description El copyright pertenece a The Rockefeller University Press
dc.description We have cloned a novel mouse CC chemokine cDNA from the lung during an allergic inflammatory reaction. The protein encoded by this cDNA is chemotactic for eosinophils, monocytes, and lymphocytes in vitro and in vivo. Based on its similarities in sequence and function with other CC chemokines, we have named it mouse monocyte chemotactic protein-5 (mMCP-5). Under noninflammatory conditions, expression of mMCP-5 in the lymph nodes and thymus is constitutive and is generally restricted to stromal cells. Neutralization ofmMCP-5 protein with specific antibodies during an allergic inflammatory reaction in vivo resulted in a reduction in the number of eosinophils that accumulated in the lung. Moreover, mMCP-5 mtkNA expression in vivo is regulated differently from that of other major CC chemokines in the lung during the allergic reaction, including Eotaxin. The presence oflymphocytes is essential for expression of mMCP-5 by alveolar macrophages and smooth muscle cells in the lung, and the induction of mMCP-5 RNA occurs earlier than that of the eosinophil chemokine Eotaxin during allergic inflammation. In contrast to Eotaxin, mR.NA for mMCP-5 can be produced by mast cells. From these results, we postulate that mMCP-5 plays a pivotal role during the early stages of allergic lung inflammation.
dc.description Peer reviewed
dc.format 3213654 bytes
dc.format application/pdf
dc.language eng
dc.publisher Rockefeller University Press
dc.rights openAccess
dc.title Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation
dc.type Artículo


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